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A daily injection of 50 mg amounts to a weekly dose of 350 mg while several depot injections easily launch the milligram content of testosterone into the four figure range(6, 18). Therefore, testosterone is a safe, low dose and well-tolerated treatment option for treating male hypogonadism. In this case, the use of testosterone replacement is only advisable over six years, after which the clinical situation will change from a clinical hyperandrogenism to a normalization of the endogenous, physiological levels of testosterone. In this scenario, the only need for testosterone replacement is to improve the patient’s quality of life.
Conclusion. This paper is the first to review, summarizing and discussing the current state of knowledge on the use of recombinant testosterone for the treatment of male hypogonadism and is the first to assess the possible risks from the initial use of testosterone for hypogonademia in men. The authors have presented evidence from randomized controlled trials to support their conclusion: the use of testosterone in men with mild hypogonadism, can help minimize and/or eliminate the problems.
We would like to thank B.H. C. S. S., D.P. W. G., G.K. S., D.D. M., S.A. B. M., M.J. E., R.E. C. M. and K.J. Y. for providing the data from and supporting this paper.
1 Vigna MS Glase M C.M. et al. The association between short- and long-term therapy with testosterone. N Engl J Med 1994 ; 336 : 2357 – 61 . 2 McManus W Liggett JM. The management of patients with primary hypogonadism: a clinical and experimental investigation. J Clin Endocrinol Metab 1998 ; 86 : 761 – 2 . 3 McPherson B Dolan S Jr Jr. et al. Prophylactic suppression of androgen levels in hypogonadal men using oral testosterone enanthate: a randomized, double-blind, placebo-controlled trial. J Clin Endocrinol Metab 1999 ; 8 : 3239 – 46 . 4 Tannock M. The use of oral testosterone for male hypogonadism. J Clin Endocrinol Metab 1994 ; 82 : 434 – 7 . 5 Bocktingh BA. Testosterone replacement in hypogonadal men: a review of available data. J Clin Endocrinol Metab 1997 ; 83 : 541 . 6 Reuter M Pazol JM,
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